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Ingredients that foster sustainable development by aiding in climate change mitigation or adaptation, promoting water conservation, supporting a circular economy, preventing pollution, safeguarding biodiversity, or advancing a more ethical and socially just economy.

NOVOPROTEIN

RECOMBINANT HUMAN IL-1 BETA

IL-1beta can activate T cells to generate cytokines such as IL-2, IL-4 and IFN -γ, induce the expression of IL-2 receptor and promote T cell proliferation and differentiation. IL-1beta can synergize with IL-2 and IFN-γ to induce cytotoxic activity of NK cells and CTL.Capable of affiliating with IL-4 and other cytokines, IL-1beta can stimulate B cell proliferation and immunoglobulin secretion. Recombinant Human IL-1 beta is produced by E.coli expression system, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

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NOVOPROTEIN

RECOMBINANT HUMAN IL-12

Interleukin-12 (IL-12) is a heterodimeric cytokine with a variety of immunomodulatory functions. It is mainly produced by dendritic cells, macrophages, B lymphocytes, and other antigen-presenting cells (APCs). IL-12 has only one high-affinity receptor, which is mainly distributed on the surface of the activated CD8+ or CD4+ T cells and CD56+ NK cells. IL-12 regulates the differentiation of Th0 cells to Th1 cells, promotes the proliferation of Th1 cells, and induces the production of IFN-gamma by NK cells and T cells. This can improve the killing activity of NK cells and LAK cells and promote the formation of specific CTL cells, thus displaying a good anti-tumor effect. Recombinant Human IL-12 is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

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NOVOPROTEIN

RECOMBINANT HUMAN IL-2

IL-2, also known as T cell growth factor (TCGF), is the most important cytokine that causes T cell proliferation. IL-2 specifically binds to the IL-2 receptor (IL-2R) on the surface of T cells to activate T cells, for proliferation. Besides, IL-2 stimulates the growth of NK cells and enhances lethality of NK cells. IL-2, together with other T cell growth factors from the family activates and duplicates CD4+ and CD8+T cells by the common receptors. IL-2 activates T cells and NK cells by autocrine and paracrine modes. Unlike T cells, NK cells do not express alpha receptor subunit and therefore have a low affinity for IL-2. However, IL-2 can promote NK cell proliferation, enhance cell activity and generating other cytokines. B cells are also activated by IL-2, which leads to proliferation and cell differentiation. Recombinant Human IL-2 is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

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NOVOPROTEIN

NOVOFAST DSRNA ELISA KIT

By using T7 RNA polymerase for In Vitro Transcription (IVT), a large amount of messenger RNA (mRNA) can be prepared for mRNA vaccine drug development and other related studies. During this reaction, double-stranded RNA (dsRNA) were generated due to different reasons such as sequence structure, T7 RNA polymerase and preparation of reaction system. dsRNA is a pathogen-associated molecular pattern (pathogen-associated Molecular pattern) that can be recognized by multiple pattern receptors of cytoplasmic species, triggering activation of immune pathways, leading to translational inhibition and degradation of mRNA vaccines which affects the ultimate safety and effectiveness of the vaccine. Therefore, it is important to identify, quantify and control dsRNA in the process of mRNA vaccine development. This kit uses double antibody sandwich enzyme-linked immunoassay (ELISA) to detect dsRNA, which can detect and quantify dsRNA residue in mRNA with high sensitivity and specificity.

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NOVOPROTEIN

MRNA CAP 2′-O-METHYLTRANSFERASE, GMP GRADE

With S-adenosylmethionine (SAM) as the methyl group base donor, mRNA Cap 2´-O-Methyltransferase can add a methyl group to the 2´-O of the first nucleotide of the Cap0 structure, [m7GpppN1(pN)x-OH(3')], next to the RNA 5´ end. Methylation of capped mRNA from Cap 0 to Cap1 naturally exists in eukaryocyte, where the Cap1 structure shows an important effect for translation, thus for expression as well. This product doesn’t show a reactivity to RNA substrate other than RNA with Cap0 structure. This product is from a large scale GMP leveled recombinant Cap 2’-O-Methyltransferase production via E. coli expression. Applying pharmaceutical leveled adjuvant and material for production, strictly controlling host protein residues, nucleic acid residues and other impurities, we guarantee manufacture and quality control practice complying to GMP regulation, as well as all the materials traceable. This product has completed the DMF record of FDA and passed the HALAL certification.

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NOVOPROTEIN

DNASE I, GMP GRADE

DNase I (Deoxyribonuclease I) was initially isolated from bovine pancreas. It can randomly degrade single stranded or double stranded DNA with equal efficiency, generating oligonucleotides with 5’-P. The bioactivity of DNase I is highly dependent on Ca²⁺, Mg²⁺ or Mn²⁺. In the presence of Mg²⁺, DNase randomly cuts dsDNA; in the presence of Mg²⁺, DNase cleaves both strands of dsDNA at approximately the same site, resulting in a blunt end or a sticky end with 1 or 2 protruding nucleotides. DNase I is GMP Grade produced in Pichia pastoris. Our manufacturing processes are strictly controlled to ensure the end products free from host protein or nucleic acid contaminations and other impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing. This product has completed the DMF record of FDA and passed the HALAL certification.

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