Hematopoietic & Supportive Factors

Flt-3 Ligand (FLT3L or FLT-3L) is a ligand of class III tyrosine kinase receptor (Flt3) that is mainly expressed on hematopoietic stem cells/progenitor cells. Flt-3 Ligand is related to early hematopoietic regulation. When used in combination with cytokines such as IL-3, IL-6, and SCF, Flt-3 Ligand can exhibit a strong proliferative effect on primitive hematopoietic stem/progenitor cells. In addition, Flt-3 Ligand enhances the expansion of GM-CSF, IL-4, and TNF-alpha-induced DC cells, and exerts anti-tumor effects by promoting the proliferation, differentiation, and maturation of DC cells, NK cells, and cytotoxic T cells (CTLs) in vivo. Recombinant Human Flt-3 Ligand is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Hepatocyte growth factor (HGF) is a multifunctional factor secreted by mesenchymal cells. It stimulates the growth of a variety of epithelial, endothelial, and mesenchymal cells, as well as angiogenesis and immunomodulatory activity, and promotes cell proliferation, mobility, and invasion. Mature HGF molecules have a heterodimeric structure consisting of an α chain with a molecular weight of 53.7 KDa and an β chain with a molecular weight of 26 KDa. HGF regulates cell growth, migration, and morphogenesis by activating the tyrosine kinase signaling cascade after binding to the c-Met receptor. HGF plays a central role in angiogenesis, tumorigenesis, and tissue regeneration due to its ability to stimulate mitosis, cell motility, and stromal invasion. Recombinant Human HGF is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Interleukin-3 (IL-3), also known as a multicolony-stimulating factor, is one of the important members of the interleukin family. It is mainly produced by activated T cells, macrophages, and bone marrow stromal stem cells. IL-3 plays an important role in hematopoietic regulation and immune regulation by binding to its receptor (IL-3R). IL-3 can not only induce the proliferation and maturation of pluripotent hematopoietic progenitor cells, bone marrow cells, eosinophils, basophilic cells, erythroid cells, and megakaryocytes, but also activate the cytotoxic, bactericidal, and anti-tumor activities of macrophages. Furthermore, IL-3 can also mobilize the response of cells (such as peripheral blood stem cells) to later activated cytokines such as G-CSF, thrombopoietin, and erythropoietin. Recombinant Human IL-3 is produced by E.coli expression system, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Interleukin 6 (IL-6) is a multifunctional cytokine mainly produced by mononuclear macrophages, T cells, and B lymphocytes. It can promote the proliferation and differentiation of B cells and T cells, and enhance the cell activity of T cells, LAK cells, and NK cells. As an autocrine growth factor, IL-6 regulates the growth of tumor cells both positively and negatively, that is, it can directly act on tumor cells but can also inhibit or promote tumor growth by affecting the host environment. Therefore, IL-6 plays an important role in immune response, acute phase reaction, and hematopoietic regulation. Recombinant Human IL-6 is expressed by E. coli, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

M-CSF, also known as CSF-1, is a four alpha -helical-bundle cytokine, mainly produced by mononuclear macrophages, lymphocytes, endothelial cells, fibroblasts, epithelial cells, etc. M-CSF is the main regulator of macrophage survival, proliferation, and differentiation. M-CSF can promote and enhance the killing of macrophages on tumor cells and microorganisms, regulate the release of cytokines and other inflammatory regulators by macrophages, and stimulate cytophagocytosis. M-CSF also plays an important role in regulating osteoclast proliferation and differentiation, and regulating bone resorption, and is necessary for normal bone development. Recombinant Human M-CSF is produced by E.coli expression system, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Recombinant human tumor suppressor M (OSM) is a glycoprotein belonging to the IL-6 cytokine family, which can inhibit the proliferation of various tumor cells and induce the differentiation of certain tumor cells. OSM can promote the differentiation of embryonic stem cells (ESCs) and induce the differentiation of pluripotent stem cells (iPSCs). OSM is also involved in many biological metabolic processes, including liver development, hematopoiesis, inflammation, bone formation, and destruction. Recombinant Human OSM is expressed by E.Coli, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Platelet-Derived Growth Factor Subunit B may exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. In addition, PDGF-BB is released by platelets upon wounding and plays a more important role in stimulating adjacent cells to grow and thereby heals the wound, among the entire PDGF growth factor family. Recombinant Human PDGF-BB is produced by E.coli expression system, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

SCF, one of hematopoietic growth factors, is an important multifunctional cytokine. SCF can stimulate the proliferation of early stem cells and the proliferation and expansion of hematopoietic colony cells, as well as promote the survival, differentiation, and mobilization of bone cells, erythroid precursor cells, and megakaryocytes. Recombinant Human SCF is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Thrombopoietin (TPO) is a highly specific platelet-stimulating factor. It can effectively increase platelet levels, promote the activity of other hematopoietic cell lines, and stimulate the production of megakaryocytes. Recombinant Human TPO is expressed by mammalian cells，and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

VEGF (or VEGF-A) is a disulfide-linked dimeric growth factor, a member of the PDGF family, with an amino acid sequence containing eight cysteine residues that form a conserved disulfide linkage. VEGF is required during embryogenesis to regulate endothelial cell proliferation, migration and survival. In adults, VEGF acts mainly in wound healing and in the female reproductive cycle. Pathologically, it is involved in tumour angiogenesis and vascular leakage. VEGF is produced by cells such as endothelial cells, macrophages and T cells. At least five isoforms with different amino acid lengths, such as VEGF121, VEGF145, VEGF165, VEGF185, and VEGF206, are present in the human body due to different shearing of mRNA. Among them, VEGF165 is the most abundant and potent isoform with potent pro-angiogenic effects, stimulating endothelial cell proliferation and survival, promoting angiogenesis and increasing vascular permeability. Recombinant human VEGF165 protein is expressed by E.coli, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.