DKSH North America is Proud to Announce its New Partnership with Exsymol.

Alistisilane® is a high-performance active ingredient that combines Carcinine (decarboxycarnosine), a potent anti-glycation peptide, with bioavailable silicium. This unique synergy delivers targeted action at the cellular level to support skin structure and vitality. It promotes re-vascularization, enhances skin resilience, and helps reduce visible signs of aging, offering a comprehensive solution for skin longevity and rejuvenation. Silicium and Carcinine join forces for powerful synergistic effects. Carcinine, a derivative of carnosine, is renowned for its strong antioxidant and anti-glycation properties, helping to protect skin cells from oxidative stress and structural degradation. Combined with bioavailable silicium, this duo supports skin regeneration, revascularization, and long-term resilience—delivering a targeted approach to combat visible signs of aging.

Alistisilane's Mechanisms of Action
• Anti-glycation: Breaks the glycation cycle, limits AGEs formation (Advanced Glycation End-products), and protects endothelial cells from senescence. It also defends existing fibers from glycation and supports the formation of new ones.
• Matrix Restructuration: Stimulates collagen production and re-organizes collagen fibers, improving skin density and firmness while visibly reducing wrinkles and filling creases. 
• Re-Vascularization: Restores optimal vascularization by enhancing endothelial cell proliferation and strengthening the cohesion between blood vessels and the matrix. Thanks to the bioavailable silicium, it supports the formation of new blood capillaries, improving cell nutrition and activity for healthier, more resilient skin.
 

Clinical Skin Benefits
A clinical study of 30 women, ages 40 to 60, showed that application of the product over a period of 56 days, improved:
• Face contour / Lift: With a 10% reduction in jowl ptosis (sagging)
• Wrinkle Lift / Plumping: With a 20% reduction in wrinkle depth
• Skin smoothness: With a 16% decrease in roughness
• Radiance: With a 43% increase in healthy-glow effect

ALGISIUM is a unique cosmetic solution to reload the skin with silanol that contains a core of organic Silicium which is one of the three cosmetic star ingredients (HA, collagen, Silicium) and provides the skin with fast physical benefits and mid-long term biological benefits. ALGISIUM ensures an optimal adaptation of the skin and preserves its viscoelasticity by awakening its natural intelligence (N.I.)

ALISTIN is known as a multi potent detoxifier for its unique abilities to prevent, repair and treat consequences of glycoxidation. ALISTIN is one of the reference active ingredient for well aging (multi detox and photoprotection) but also for amazing glow benefits.

ADENOSILANE is a silanol from EXSYMOL technology: biofunctional Silicium + Adenosine. Adenosilane revitalizes the pore sheath to retain its grip and prevent loosening.

EPIDERMOSIL is the next generation of Hyaluronic Acid by combining it with our bioavailable silicium. HA with a medium molecular weight 150-600 kDa targets keratinocytes in the basal lamina of the epidermis.

D.S.B. C is a silanol specialized in anti-inflamm’aging (avoiding any source of inflammation giving rise to premature aging). It has a core of organic silicon which potentializes the salicylic acid with which it has been combined. The organic silicon restructures the skin and balances the metabolisms of all skin cells providing an overall action on the skin. Potentialized salicylic acid has a preventive action on inflammation and a soothing effect, without causing irritation on the skin’s surface.

CHRONOCYCLIN® is an anti-aging chronopeptide that mimics sun exposure activation of the circadian genes and optimizes skin physiological activities of defense and cells regeneration.

CAPALGIN® is obtained by extraction from red winter algae. Controlling growing, harvesting and the method of extraction allows concentrations of citrullinyl-arginine and taurine to be optimized, two molecules that stimulate hair growth.

D.S.H. CN® is a super moisturizer as it combines the hydration properties of the organic silicium core and of the hyaluronic acid (HA). The high molecular weight hyaluronic acid will form a film at the surface of the skin hence preventing trans-epithelial water loss (TEWL). As a result , not only will skin have a nice feel, but it will be highly hydrated.

G.P.S.® combines the Silanol properties, restructurant of the connective tissue, therefore accountable for a maximized moisturization, to that of trehalose, a disaccharide capable, in situation of extreme dehydration, of substitution with water in the tissue.

LIPOSILIOL is a liposoluble silanol specializing in anti-oxidation. It has a core of organic silicon which potentializes Vitamin E, with which it has been combined.

PANTESINOL is a silanol with an organic silicon core combined with panthenol (or provitamin B5). The organic silicon restructures the skin and balances the metabolisms of all skin cells providing an overall action on skin. In the hair, silicon interacts with keratin fibers to strengthen the shaft and restore the cuticle.

PRO-D.S.B. by Exsymol acts as an anti-inflammatory, anti-aging, soothing and moisturizing agent. It is a chemicaly pure silicon organic derivative. Due to the silanol structure, PRO-D.S.B. exhibits antioxidant and restructuring activity. it stimulates growth acceleration and metabolism of hair and nails. It is neither toxic nor irritating in nature. PRO-D.S.B. finds application in formulating products for acneic skin, sensitive skin, sun & after-sun, after-shave, post depilatory and peel-off use (to restore functional pH of the skin). Moreover, it is used in color cosmetics, hair products and nail treatments.

SIRHMANOSE is a SILANOL (its core is a biomimetic form of silicium found in our body) that creates a synergy between this key component of the skin and a plant natural sugar: rhamnose.

THEOPHYLLISILANE C® acts as an anti-aging, firming and regenerative (repairing) agent. It offers elasticity, density, restructuring and protection to the skin. It allows maximum slimming and firming effect. It exhibits lipolytic activity which is accompanied by regeneration of connective tissues, allowing a better micro-circulation. It is a silanol obtained by reaction between theophylline acetic acid and alginic acid. Moreover, it normalizes cellular exchanges and improves the appearance of the skin. It is preservative-free, non-toxic and non-irritating.

TYROSILANE® by Exsymol acts as an anti-aging and regenerating (repairing) agent. It is a silanol, obtained from the reaction of methylsilanetriol with N-acetyl-tyrosine. It exhibits tanning activation efficacy due to its direct effect on melanocytes and keratinocytes-melanocytes communication. It offers softness, firmness, density and elasticity. It provides plumping effect, better hydration, cell-membrane restructuring and protection from free-radicals. It prevents graying of hair. It is neither toxic nor irritant in nature. TYROSILANE finds application in formulating products for tanning activation, anti-aging, anti-wrinkle, face-, hair & body care products.

ALB ATIN® by Exsymol acts as an anti-aging and skin lightening agent. It is a preservative-free, non-tyrosine based inhibitor that provides melanogenesis inhibition. It offers whitening effect, blemish correction and uniform complexion. Its activity is optimized when associated with ascorbic acid, kojic acid, arbutin etc. It shows very good stability in the aqueous phase of a gel, emulsion or solution. It is non-irritant and non-cytotoxic in nature. It is suitable for sensitive skin. ALBATIN finds application in formulating day-care products, anti-age spots cream and skin lightening products.

GLUTRAPEPTIDE® is a second generation neuroprotector. It potentializes neuronal response to NGF and therefore slows down the neurodegenerescence induced by the decrease of NGF levels.

METHIOPEPTIDE® is a preservative-free 15% hydroglycolic solution of AMDM (Acetyl methionyl decarboxymethionine), a « biobetter » peptide derived from dimethionine.

ENTADINE helps delay the negative effects of overexposure to radiation. ENTADINE also offers overall skin care, protecting it from intense exposure or in the long term to combat photo-aging.

PHYKOSIL 2000 is an active ingredient obtained from the micro-grinding of cells of a red alga rich in biologically active silicon.