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HEXAFLUOROISOPROPANOL (HFIP) is an acidic alcohol and due to its strong hydrogen bonding properties it can be used as a solvent for many different kinds of polymers. It is used as an intermediate to prepare pharmaceuticals.

2,2,2-TRIFLUORETHANOL is used as a solvent in applications of the pharmaceutical field. Oxidations of sulfur compounds using hydrogen peroxide are effectively conducted in TFE. It can also be used as a protein denaturant. In biology TFE is used as a co-solvent in protein folding studies with NMR spectroscopy: this solvent can effectively solubilize both peptides and proteins. Depending upon its concentration, TFE can strongly affect the three-dimensional structure of proteins.