Biopharma

Enterokinase (light chain), highly specifically recognizes the Asp-Asp-Asp-Asp-Lys sequence and hydrolyzes the polypeptides at the C-terminus of Lys. It can convert trypsinogen to trypsin in vivo, and fusion proteins with this recognition sequence can also be cleaved. This product, enterokinase, produced by recombinant yeast secretion and expression system, is of a high purity, high bio-activity, and an excellent stability, which allows a wide range of working condition (4-45℃, pH 4.5-9.5) even keeps a part of bio-activity in the presence of various detergent and denatured agents. This product is from a large scale GMP leveled recombinant enterokinase production via Pichia pastoris expression. Applying pharmaceutical leveled adjuvant and material for production, strictly controlling host protein residues, nucleic acid residues and other impurities, we guarantee manufacture and quality control practice complying to GMP regulation, as well as all the materials traceable.

DNase I (Deoxyribonuclease I) was initially isolated from bovine pancreas. It can randomly degrade single stranded or double stranded DNA with equal efficiency, generating oligonucleotides with 5’-P. The bioactivity of DNase I is highly dependent on Ca²⁺, Mg²⁺ or Mn²⁺. In the presence of Mg²⁺, DNase randomly cuts dsDNA; in the presence of Mg²⁺, DNase cleaves both strands of dsDNA at approximately the same site, resulting in a blunt end or a sticky end with 1 or 2 protruding nucleotides.  DNase I is GMP Grade produced in Pichia pastoris. Our manufacturing processes are strictly controlled to ensure the end products free from host protein or nucleic acid contaminations and other impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing. This product has completed the DMF record of FDA and passed the HALAL certification.