Biopharma

CD40L, also known as CD154, is a plasma membrane glycoprotein and differentiation antigen expressed on the surface of T cells. It stimulates the proliferation of B cells to secrete various immunoglobulins in the presence of cytokines. CD40L can induce the cytokines secretion of peripheral blood mononuclear cells, so produce anti-tumor activity. It also has a co-stimulatory effect on the proliferation of activated T cells, accompanied by the production of IFN-gamma, TNF-alpha, and IL-2. Recombinant Human sCD40L is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

RNase Inhibitor inhibits RNase A, B and C with high efficiency by forming a 1:1 complex with them. The characteristics of RNase Inhibitor are similar to those derived from pig liver and human placenta. The inhibition is reversible, as the complex can be dissociated by urea and sulfhydryl reagents in which RNase refolds and the inhibitor is inactivated. It can be directly added to the reaction containing RNA. Different from other competitive inhibitors (e.g., nucleic acids, inorganic phosphoric acids), this product is a protein, which can be easily removed from the reaction by phenol extraction. However, the reverse transcriptase RNase H could not be inhibited. Recombinant RNase Inhibitor is GMP Grade produced in E. coli. Our manufacturing processes are strictly controlled to ensure the end products free from host protein or nucleic acid contaminations and other impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing. This product has completed the DMF record of FDA and passed the HALAL certification.

Vitronectin is a large glycoprotein found in blood and the extracellular matrix (ECM). The gene for Vitronectin encodes a 19 amino acid (aa) signal peptide and a 459 aa protein. The apparent molecular weight of human Vitronectin is 75 kDa, with ~30% of its molecular mass being attributed to glycosylation at 3 different sites. Vitronectin is involved in a number of biological activities including cell adhesion, cell spreading and migration, cell proliferation, extracellular anchoring, fibrinolysis, hemostasis, and complement mediated immune defense. It is worth noting that in the culture of pluripotent stem cells, due to the clear chemical composition of the protein, Recombinant Human Vitronectin helps to reduce the instability, compared with human plasma-derived Vitronectin and basement membrane extracts (BMEs). Recombinant Human Vitronectin is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

S-(5’-Adenosyl)-L-methionine (SAM, AdoMet) with an activating methyl group is the methyl donor for vaccinia capping enzyme and mRNA Cap 2’-O-Methyltransferase catalyzed methylation, the storage buffer formula is: 0.005M Sulfuric Acid, 10% ETOH. SAM processes are strictly controlled to ensure the end products free from impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing. This product has passed the HALAL certification.