Tscm Expander® is a mixing of cytokines (IL-7, IL-15, etc.) at a certain proportion. It specifically expands the T-memory stem cells and significantly extends the in vivo post-infusion survival time of T cells with specific killing ability, thus remarkably improving the efficacy of immune cell therapy against the tumor. In the traditional cell expansion procedures, after the monocytes activated by CD3/CD28 monoclonal antibodies are further expanded by IL-2, the majority of T cells highly differentiate to effector/memory T cells. These cells are weak in self-renewal ability with short post-infusion survival time in vivo, resulting in poor therapeutic effects. Tscm Expander® takes the place of IL-2 in the expansion of activated T cells so that 30% of the expanded T cells are transformed into T-memory stem cells. This greatly prolongs the post-transplant survival time of immune cells in vivo and improves the therapeutic effect. The T memory stem cell expanders of Tscm Expander® are produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

As a biological macromolecule, mRNA can be synthesized on a large scale by in vitro transcription (IVT). T7 promoter is one of the promoters with the highest transcription efficiency. Therefore, T7 RNA Polymerase can be used for in vitro transcription to obtain more synthetic products. T7 RNA Transcription Enzyme Mix has been optimized by a series of transcription systems. One reaction can transcribe up to 150-200μg of RNA, and the synthesized RNA can be used downstream in many aspects such as mRNA vaccine preparation, RNA structure and function research, RNase protection, probe hybridization, RNAi, microinjection and in vitro translation application. The original enzymes of T7 RNA Transcription Enzyme Mix produced in E. coli. Our manufacturing processes are strictly controlled to ensure the end products free from host protein or nucleic acid contaminations and other impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing. This product has passed the HALAL certification.

As a biological macromolecule, mRNA can be synthesized on a large scale by in vitro transcription (IVT). T7 promoter is one of the most efficient promoters at present. Therefore, T7 RNA polymerase can be used for in vitro transcription to obtain more synthetic products. T7 RNA polymerase is a T7 promoter-specific, DNA-dependent, 5'→3' RNA polymerase from T7 bacteriophage. Using double stranded DNA as the template, it transcribes RNA complementary to the single stranded DNA located at the downstream of T7 promoter. T7 RNA polymerase has been commonly used for in vitro mRNA synthesis. The polymerase is GMP Grade produced in E. coli. Our manufacturing processes are strictly controlled to ensure the end products free from host protein or nucleic acid contaminations and other impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing. This product has completed the DMF record of FDA and passed the HALAL certification.

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