Glial cell line-derived neurotrophic factor (GDNF) is a disulfide-linked homodimeric glycoprotein that belongs to the TGF-β superfamily. It has been shown to promote the survival of different subpopulations of neurons in both the central and peripheral nervous systems at various stages of development. Human GDNF cDNA encodes a 211 amino acid precursor, which is processed to produce the dimeric protein. Mature human GDNF is expected to contain two subunits, each with 134 amino acid residues. Cells known to express GDNF include supporting cells, type I astrocytes, Schwann cells, neurons, pinealocytes, and skeletal muscle cells. Mutations in this gene may be associated with congenital megacolon. Recombinant Human GDNF is expressed by E.coli, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Hepatocyte growth factor (HGF) is a multifunctional factor secreted by mesenchymal cells. It stimulates the growth of a variety of epithelial, endothelial, and mesenchymal cells, as well as angiogenesis and immunomodulatory activity, and promotes cell proliferation, mobility, and invasion. Mature HGF molecules have a heterodimeric structure consisting of an α chain with a molecular weight of 53.7 KDa and an β chain with a molecular weight of 26 KDa. HGF regulates cell growth, migration, and morphogenesis by activating the tyrosine kinase signaling cascade after binding to the c-Met receptor. HGF plays a central role in angiogenesis, tumorigenesis, and tissue regeneration due to its ability to stimulate mitosis, cell motility, and stromal invasion. Recombinant Human HGF is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

VEGF (or VEGF-A) is a disulfide-linked dimeric growth factor, a member of the PDGF family, with an amino acid sequence containing eight cysteine residues that form a conserved disulfide linkage. VEGF is required during embryogenesis to regulate endothelial cell proliferation, migration and survival. In adults, VEGF acts mainly in wound healing and in the female reproductive cycle. Pathologically, it is involved in tumour angiogenesis and vascular leakage. VEGF is produced by cells such as endothelial cells, macrophages and T cells. At least five isoforms with different amino acid lengths, such as VEGF121, VEGF145, VEGF165, VEGF185, and VEGF206, are present in the human body due to different shearing of mRNA. Among them, VEGF165 is the most abundant and potent isoform with potent pro-angiogenic effects, stimulating endothelial cell proliferation and survival, promoting angiogenesis and increasing vascular permeability. Recombinant human VEGF165 protein is expressed by E.coli, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Thrombopoietin (TPO) is a highly specific platelet-stimulating factor. It can effectively increase platelet levels, promote the activity of other hematopoietic cell lines, and stimulate the production of megakaryocytes. Recombinant Human TPO is expressed by mammalian cells，and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.