Glial cell line-derived neurotrophic factor (GDNF) is a disulfide-linked homodimeric glycoprotein that belongs to the TGF-β superfamily. It has been shown to promote the survival of different subpopulations of neurons in both the central and peripheral nervous systems at various stages of development. Human GDNF cDNA encodes a 211 amino acid precursor, which is processed to produce the dimeric protein. Mature human GDNF is expected to contain two subunits, each with 134 amino acid residues. Cells known to express GDNF include supporting cells, type I astrocytes, Schwann cells, neurons, pinealocytes, and skeletal muscle cells. Mutations in this gene may be associated with congenital megacolon. Recombinant Human GDNF is expressed by E.coli, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Hepatocyte growth factor (HGF) is a multifunctional factor secreted by mesenchymal cells. It stimulates the growth of a variety of epithelial, endothelial, and mesenchymal cells, as well as angiogenesis and immunomodulatory activity, and promotes cell proliferation, mobility, and invasion. Mature HGF molecules have a heterodimeric structure consisting of an α chain with a molecular weight of 53.7 KDa and an β chain with a molecular weight of 26 KDa. HGF regulates cell growth, migration, and morphogenesis by activating the tyrosine kinase signaling cascade after binding to the c-Met receptor. HGF plays a central role in angiogenesis, tumorigenesis, and tissue regeneration due to its ability to stimulate mitosis, cell motility, and stromal invasion. Recombinant Human HGF is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

10×XbaI Reaction Buffer, GMP Grade is a reaction buffer for restriction endonuclease XbaI This product is produced with pharmaceutical specifications of raw materials, and strictly control all kinds of pollution in the production process. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing.

Restriction endonucleases are a class of endonuclease that recognize specific deoxynucleotide sequences and cleave the phosphodiester bond between two deoxyribonucleotides at specific sites in each chain. BsaI derived from Bacillus Thermophilus, is a commonly used restriction endonuclease. BsaI recognizes the following sequence: 5’…GGTCTC(N)1↓…3’; 3’…CCAGAG(N)5↑…5’. Our manufacturing processes are strictly controlled to ensure the end products free from host protein or nucleic acid contaminations and other impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing. This product has completed the DMF record of FDA.