IL-21, is a kind of Type I Cytokine, highly homogeneous with IL-2, IL-4, IL-15, etc, sharing γ c receptor subunit and cytokine specific receptor Alpha subunit with IL-7 and IL-9. In vivo IL-21 is produced by activated CD4+T cells and has various bioactivities, stimulating CD4+ and CD8+T cell proliferation and NK cell toxicity without triggering activation-induced apoptosis. Although the mechanism of IL-21 in Th1/Th2 differentiation is not clear yet, IL-21 plays an important role in humoral immunity and regulating natural/acquired immunity. Due to the important function of IL-21 in enhancing the proliferation and differentiation of antigen specific T cells in vitro, it has been more and more widely applied in immune cell therapy. Recombinant Human IL-21 is produced by E.coli expression system, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Interleukin-12 (IL-12) is a heterodimeric cytokine with a variety of immunomodulatory functions. It is mainly produced by dendritic cells, macrophages, B lymphocytes, and other antigen-presenting cells (APCs). IL-12 has only one high-affinity receptor, which is mainly distributed on the surface of the activated CD8+ or CD4+ T cells and CD56+ NK cells. IL-12 regulates the differentiation of Th0 cells to Th1 cells, promotes the proliferation of Th1 cells, and induces the production of IFN-gamma by NK cells and T cells. This can improve the killing activity of NK cells and LAK cells and promote the formation of specific CTL cells, thus displaying a good anti-tumor effect. Recombinant Human IL-12 is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Interleukin 6 (IL-6) is a multifunctional cytokine mainly produced by mononuclear macrophages, T cells, and B lymphocytes. It can promote the proliferation and differentiation of B cells and T cells, and enhance the cell activity of T cells, LAK cells, and NK cells. As an autocrine growth factor, IL-6 regulates the growth of tumor cells both positively and negatively, that is, it can directly act on tumor cells but can also inhibit or promote tumor growth by affecting the host environment. Therefore, IL-6 plays an important role in immune response, acute phase reaction, and hematopoietic regulation. Recombinant Human IL-6 is expressed by E. coli, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

IL-2, also known as T cell growth factor (TCGF), is the most important cytokine that causes T cell proliferation. IL-2 specifically binds to the IL-2 receptor (IL-2R) on the surface of T cells to activate T cells, for proliferation. Besides, IL-2 stimulates the growth of NK cells and enhances lethality of NK cells. IL-2, together with other T cell growth factors from the family activates and duplicates CD4+ and CD8+T cells by the common receptors. IL-2 activates T cells and NK cells by autocrine and paracrine modes. Unlike T cells, NK cells do not express alpha receptor subunit and therefore have a low affinity for IL-2. However, IL-2 can promote NK cell proliferation, enhance cell activity and generating other cytokines. B cells are also activated by IL-2, which leads to proliferation and cell differentiation. Recombinant Human IL-2 is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.