Recombinant Anti-Human CD3 mAb is a T cell-activated antibody produced based on OKT3 through humanization modification and genetic engineering. On the premise of maintaining the activation ability of OKT3 monoclonal antibody on T cells, the product can eliminate the immunogenicity of murine antibodies to the greatest extent. The product recognizes the human TCR ε chain to activate the T cell activation signaling pathway, thus stimulating T cell activation and proliferation. Recombinant Anti-Human CD3 mAb is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Inorganic Pyrophosphatase catalyzes the hydrolysis of inorganic pyrophosphate into two orthophosphates: Applied in nucleic acid amplification experiments, PPase can hydrolyze the inorganic pyrophosphate generated by the polymerization to avoid its inhibition effect to synthesis of RNA strand. Pyrophosphatase, Inorganic (yeast) is GMP Grade produced in E. coli. Our manufacturing processes are strictly controlled to ensure the end products free from host protein or nucleic acid contaminations and other impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing. This product has completed the DMF record of FDA and passed the HALAL certification.

CD28 molecule is present on the surface of most T cells and is considered a surface molecule unique to T cells. However, not only the first signal of the T lymphocyte receptor (TCR)/CD3 complex is required during the full activation of T lymphocytes, but also the second signal, to enhance the activation and proliferation of T lymphocytes. The synergistic stimulation molecule CD28 is present on the surface of T lymphocytes, and its interaction with its ligand B7 is one of the major pathways to provide the second signal for T lymphocyte activation. T lymphocytes will be fully activated if the second signal is provided through the synergistic stimulation of the CD28 antibody while providing the first signal using the simulation of the CD3 antibody in vitro. Recombinant Anti-Human CD28 mAb is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Inorganic Pyrophosphatase (PPase) catalyzes the hydrolysis of inorganic pyrophosphate into two orthophosphates: Applied in nucleic acid amplification experiments, PPase can hydrolyze the inorganic pyrophosphate generated by the polymerization to avoid its inhibition effect to synthesis of RNA strand. In the production process of mRNA vaccine drugs, PPase can increase the production amount of mRNA. According to regulations, various residues should be detected for mRNA vaccine solution, among which, PPase, as a protein product, belongs to the category of protein residue detection item, so quantitative detection of its residues should be carried out. This kit can detect and quantitatively analyze the PPase residues in Mrna solution with high sensitivity and specificity.