MELATREPEIN 5000 are produced in melanocytes and transferred to neighboring keratinocytes, where they are naturally degraded by autophagy. However, constant exposure to sunlight or changes in hormonal levels may force cell organelles and enzymes to lose their functions, resulting in slowdown of melanosome degradation. Accumulation of survived melanosomes in keratinocytes result in skin pigmentation. MelaTrepein^TM5000 is a dual targeting solution to prevent or reduce skin pigmentation by activating autophagic process to break down melanosomes already existing in keratinocytes, and by blocking new melanosome uptake into keratinocytes at the same time.

BETULA ALBA BARK EXTRACT can be used as skin conditioner, antioxidant, soothing and anti-allergic agents in cosmetics. It is safe for using, without causing acnes. It can inhibit the release of histamine and has anti allergic effect. It reduces elastase and metalloproteinase, with strong anti-aging effect. It can be used together with other ingredients in skincare products, aimed at skin conditioning, smoothing, preventing chaps, and improving skin tone.