2,2,2-TRIFLUORETHANOL is used as a solvent in applications of the pharmaceutical field. Oxidations of sulfur compounds using hydrogen peroxide are effectively conducted in TFE. It can also be used as a protein denaturant. In biology TFE is used as a co-solvent in protein folding studies with NMR spectroscopy: this solvent can effectively solubilize both peptides and proteins. Depending upon its concentration, TFE can strongly affect the three-dimensional structure of proteins.

TRIFLUOROACEYIC ACID is a solvent that is used in the production of pharmaceutical and agricultural chemicals as well as in many other specialized applications.