Biopharma

Flt-3 Ligand (FLT3L or FLT-3L) is a ligand of class III tyrosine kinase receptor (Flt3) that is mainly expressed on hematopoietic stem cells/progenitor cells. Flt-3 Ligand is related to early hematopoietic regulation. When used in combination with cytokines such as IL-3, IL-6, and SCF, Flt-3 Ligand can exhibit a strong proliferative effect on primitive hematopoietic stem/progenitor cells. In addition, Flt-3 Ligand enhances the expansion of GM-CSF, IL-4, and TNF-alpha-induced DC cells, and exerts anti-tumor effects by promoting the proliferation, differentiation, and maturation of DC cells, NK cells, and cytotoxic T cells (CTLs) in vivo. Recombinant Human Flt-3 Ligand is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Epidermal Growth Factor (EGF) is capable of enhancing the proliferation and differentiation of mesenchymal cells and epithelial cells. In vitro, EGF plays a role of mitogen for fibroblasts, epithelial cells, and endothelial cells, facilitating colony formation in epithelial cell culture. In vivo, EGF promotes epithelial cell and blood vessel formation and inhibits gastric acid secretion. Recombinant Human EGF is produced by E.coli expression system, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Interleukin-18 (IL-18) is a member of the IL-1 family. Its ability to induce the production of IFN-gamma is even stronger than IL-12. IL-18 can stimulate the proliferation of CD3 monoclonal antibody-activated T cells. It also acts as an activator of NK cells to enhance the cytotoxic effect of NK cells. Also, IL-18 can act synergistically with IL-12 to induce the production of IFN-gamma, improving NK cell activity and promoting T cell proliferation. Recombinant Human IL-18 is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Interleukin-12 (IL-12) is a heterodimeric cytokine with a variety of immunomodulatory functions. It is mainly produced by dendritic cells, macrophages, B lymphocytes, and other antigen-presenting cells (APCs). IL-12 has only one high-affinity receptor, which is mainly distributed on the surface of the activated CD8+ or CD4+ T cells and CD56+ NK cells. IL-12 regulates the differentiation of Th0 cells to Th1 cells, promotes the proliferation of Th1 cells, and induces the production of IFN-gamma by NK cells and T cells. This can improve the killing activity of NK cells and LAK cells and promote the formation of specific CTL cells, thus displaying a good anti-tumor effect. Recombinant Human IL-12 is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.