Creatine monohydrate is a widely researched, affordable, and popular dietary supplement form of creatine, a compound naturally found in the body and in red meat and seafood. It's a top supplement for improving muscle strength, endurance, and performance in high-intensity, short-duration activities by increasing energy production in muscle cells. Creatine monohydrate is considered safe for most healthy individuals when taken within recommended guidelines and is supported by scientific evidence for its effectiveness.