Mini DuoCol® 2% Solution: Fermentation-Derived Collagen, Bioengineered for Deep Skin Delivery
A New Chapter in Collagen Innovation
Collagen has always been one of beauty’s most powerful stories. Consumers trust it, marketers rely on it, and formulators know how difficult it is to get right. Until now, the choices were limited: animal-derived collagen or plant-based substitutes that can’t truly claim collagen on INCI.
Collagen has always been one of beauty’s most powerful stories. Consumers trust it, marketers rely on it, and formulators know how difficult it is to get right. Until now, the choices were limited: animal-derived collagen or plant-based substitutes that can’t truly claim collagen on INCI.
Trautec’s Mini DuoCol® 2% Solution is a Vegan liquid recombinant human collagen that pairs MiniReCol® 3 for Type III activity with MiniReCol® 17 to support the dermis-epidermis junction, delivering fast absorption and multi-layer skin benefits. The solution contains low molecular weight collagen (˜5 kilodaltons), which promotes rapid absorption and deep penetration into the skin. Evidence includes in vivo anti-aging data for MiniReCol® 3, transmission electron microscopy evidence for DEJ repair from MiniReCol® 17, and identity and purity confirmation by HPLC-MS. Together the data establish a mechanistic and clinical rationale for immediate sensory benefits and durable structural repair.
Why this matters to formulators and R&D
Formulators often face three key trade-offs: performance, cost, and compliance. Mini DuoCol® 2% overcomes these challenges as a true collagen (INCI-listed), available in a liquid, drop-in-ready format, and produced at scale without animal sourcing. It delivers immediate sensory benefits that support marketing claims, while also providing measurable, long-term structural improvements essential for substantiated efficacy.
Formulators often face three key trade-offs: performance, cost, and compliance. Mini DuoCol® 2% overcomes these challenges as a true collagen (INCI-listed), available in a liquid, drop-in-ready format, and produced at scale without animal sourcing. It delivers immediate sensory benefits that support marketing claims, while also providing measurable, long-term structural improvements essential for substantiated efficacy.
Key practical advantages:
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True INCI recognition: Collagen Amino Acids for defensible labelling
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Liquid, low-MW format: directly add to serums, gels, creams without rehydration hassles
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Scalable, non-animal source: fermentation, vegan and Halal compatible
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Technical support: DKSH formulation and regulatory assistance available
Beautiful Synergy: Clinical Proof & Clear Stats for Mini DuoCol® 2% Solution
Mini DuoCol® 2% Solution delivers complementary activity because MiniReCol® 3 and MiniReCol® 17 target different but synergistic layers of skin biology Mechanisms at a glance:
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MiniReCol® 3
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MiniReCol® 17
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Clinical Summary –
Before & After Effect |
In Vivo Test:
Reduction in the depth, length and number of fine lines. Collagen Density value increased significantly by 43.69% after Week 8 with the use of the 0.1% MiniReCol® 3 collagen cream.
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In Vitro Test:
Transmission electron microscopy (Hitachi) captured images of the DEJ (Dermis-Epidermis Junction) at a magnification of 60,000x. A red arrow highlights the DEJ structure, with damage indicated in the NC (Negative Control) group.
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Key Benefits
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Product features
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From Breakthrough to Scale With DKSH
Mini DuoCol® 2% Solution was developed by Trautec, a U.S. biotech innovator holding exclusive IP in recombinant collagen, in collaboration with the DKSH North America Innovation Center. Their breakthrough wasn’t just producing collagen through fermentation, it was making it scalable, high-purity, and fully compatible with human skin. Today, DKSH brings this breakthrough to market with exclusive global distribution of Mini DuoCol® 2% Solution.
Through DKSH, you gain more than an ingredient:
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Technical support to accelerate formulation
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Regulatory clarity so claims are defensible
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Market insights to position launches for maximum impact
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Pipeline Growth: Mini DuoCol® 2% Solution is available now, with different preservative system options coming in October 2025, and three additional collagen solution variants currently in development.
Mini DuoCol® 2% Solution is more than an ingredient. It’s a platform for growth.
What You Need to Do Next
For formulators, marketers, and product leaders, this is more than “nice to know.” It’s a chance to:
For formulators, marketers, and product leaders, this is more than “nice to know.” It’s a chance to:
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Cut R&D timelines with liquid collagen that’s easy to use.
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Differentiate launches with true INCI collagen.
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Strengthen claims and pricing power with visible results.
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Position your brand as a first-mover in biotech beauty.
Click the “Download” button at the top right to explore our Mini DuoCol® 2% Solution Explainer. Sign up on Discover to request samples and talk to DKSH experts about your next launch.
FAQ
1. What makes Mini DuoCol® 2% Solution unique?
A vegan, fermentation-derived collagen with fast absorption and deep skin repair benefits.
2. Is Mini DuoCol® 2% suitable for all skin types?
Yes, it’s 100% bioengineered, vegan, and highly compatible with human skin.
