HydraSynol® DOI by Sytheon: The Smart Skin Hydrator and Barrier Builder
In the evolving landscape of skincare and personal care formulations, hydration remains the cornerstone of healthy, resilient skin. HydraSynol® DOI, developed by Sytheon, stands as a breakthrough ingredient designed to not only deliver deep hydration but also strengthen the skin barrier at the molecular level. With its INCI name Isosorbide Dicaprylate, this innovative compound is derived from natural sources and is supported by robust clinical and molecular evidence that highlights its efficacy and versatility.
Skin hydration is often oversimplified as merely trapping moisture on the surface. Conventional products rely on humectants and occlusives that lock in water temporarily, but this approach does not address the deeper mechanisms of hydration. HydraSynol® DOI introduces a smarter concept by stimulating Aquaporin-3 channels within skin cells, which distribute water where it is needed most. Clinical studies demonstrate that this unique action provides controlled and long-lasting hydration lasting more than 48 hours, with results tailored to the severity of dryness. Severely dry skin receives greater hydration while moderately dry skin benefits from balanced replenishment.
Beyond hydration, HydraSynol® DOI reinforces the barrier function of the skin. It has been shown to upregulate key genes and proteins such as tight junctions, desmosomes, and ceramide synthase, all of which play vital roles in maintaining skin integrity and reducing transepidermal water loss. In a clinical trial, a 2% HydraSynol® DOI formulation delivered a 15% reduction in water loss across the skin barrier, underscoring its role as a true barrier builder.
Another distinguishing feature is its synergy with glycerol. When combined at equal concentrations, the two actives demonstrate enhanced hydration benefits, showcasing a synergistic effect greater than when used alone. This makes HydraSynol® DOI an ideal candidate for next-generation moisturizers, body care products, and facial treatments.
HydraSynol® DOI also adds value to sun care and glow formulations. In clinical testing, its inclusion in dihydroxyacetone-based self-tanning products amplified tanning results within days while improving overall skin hydration. This dual benefit enhances consumer appeal by ensuring that skin not only looks radiant but also feels nourished and smooth.
Its versatility extends into hair care where it provides a sustainable, silicone-free alternative that delivers shine and gloss comparable to phenyltrimethicone, yet with the added benefit of biodegradability and eco-friendliness. This positions HydraSynol® DOI as a solution aligned with modern consumer preferences for effective yet environmentally responsible formulations.
From a formulation perspective, HydraSynol® DOI is easy to incorporate into emulsions, hydro-lipid dispersions, and anhydrous systems. It is miscible with a wide variety of emollients and oils and shows stability even at elevated temperatures. Its recommended usage level is between 2 to 4 percent, with optimal performance observed when combined with glycerol in acidic formulations below pH 6.5.
HydraSynol® DOI is fully compliant with international regulations, COSMOS approved, REACH registered, and globally accepted for use in personal care products. Its foundation in green chemistry and proven efficacy make it a powerful ingredient for formulators seeking to develop advanced hydration and barrier care solutions that meet the growing consumer demand for performance-driven and sustainable beauty products.
With its dual role as a smart hydrator and barrier builder, HydraSynol® DOI by Sytheon represents the future of hydration science. It is more than a moisturizer. It is a scientifically advanced solution that optimizes water distribution within the skin, strengthens the skin barrier, and enhances product performance across skincare, sun care, body care, and hair care applications.
Discover the science of smart hydration with HydraSynol® DOI. Register now on DKSH Discover to learn more, request samples, and explore formulation opportunities.
