藥物成分

Fibronectin (rFN-CH296, NovoNectin) is involved in cell attachment, spreading, differentiation, and proliferation. It can greatly improve the infection efficiency of retroviruses on mammalian cells. VLA-4 and VLA-5 on the cell surface bind to the CS-1 site and the cell-binding domain on NovoNectin, respectively, and the retroviral vector binds to the heparin-binding domain, thus promoting the transfection efficiency of retroviruses and lentiviruses on cells. NovoNectin® can be mixed with anti-Human CD3 mAb for coating to enhance T cell amplification. Recombinant Human NovoNectin is expressed by E. coli, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Activin A (Act A) belongs to TGF- β Members of the family are dimeric proteins linked by disulfide bonds, originally extracted from the gonads and capable of stimulating the release of pituitary follicle stimulating hormone (FSH). Activin A has a wide range of biological activities and is involved in regulating many different functions, including hypothalamic and pituitary hormone secretion, gonadal hormone secretion, Germ cell development and maturation, red blood cell differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth. Recombinant Human Activin A is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.

Glypicans (GPC) are a family of heparan sulfate proteoglycans that are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor. GPC3 is closely related to the occurrence and progression of hepatic cancer, melanoma, and ovarian clear cell carcinoma. GPC3 expression is featured by high specificity. GPC3 is highly expressed in hepatic cancer and lowly expressed in melanoma, ovarian clear cell carcinoma, yolk sac tumor, neuroblastoma, hepatoblastoma, and Wilm tumor, but not expressed in breast cancer, mesothelioma, ovarian epithelial cancer, or lung cancer. GPC3 is hardly expressed in normal human tissues, so it is expected to become one of the ideal targets for liver cancer immunotherapy. Recombinant Human GPC3 is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.