Methocarbamol is a medication used for short-term musculoskeletal pain. It may be used together with rest, physical therapy and pain medication. It is less preferred in low back pain. It has limited use for rheumatoid arthritis and cerebral palsy.

Metaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression.

Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent.