Sodium hydroxide solution can be used in biopharmaceutical processes (both upstream and downstream).

PMSF is often used in lysis buffer to assist in preserving proteins of interest during protein isolation and sample preparation.

Tromethamine can be used in biopharmaceutical buffer formulations (both upstream and downstream), electrophoresis separations and diagnostic reagent formulations. Tromethamine is especially useful in downstream purification processes.